
Experimental protocol. Credit score: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (2024). DOI: 10.1152/ajpregu.00073.2024
Physique place can have an effect on the accuracy of important signal measurements that point out arterial stiffness—a danger issue for coronary heart illness—in response to new analysis. Sitting down throughout sure assessments could trigger a spike in arterial stiffness readings that doesn’t mirror a real enhance.
The examine is revealed within the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology and has been chosen as an APSselect article for February.
Arterial stiffness is when the partitions of the blood vessels aren’t as elastic or stretchy as they need to be. The situation is usually part of growing old and can even happen in individuals who have diabetes, excessive ldl cholesterol or hypertension. Individuals with stiffer arteries have an elevated danger of coronary heart assault, stroke and different types of coronary heart illness.
Medical professionals mostly measure markers of arterial stiffness with sufferers mendacity on their again (supine place). Nonetheless, sitting could also be a extra sensible choice for folks with continual again ache or different well being considerations.
On this examine, researchers explored whether or not measuring carotid-femoral pulse wave velocity—the time it takes for the heart beat to journey from the carotid to the femoral artery—might be thought of dependable when measured in a seated place. Carotid-femoral pulse wave velocity (cfPWV) is taken into account the “gold normal” for measuring arterial stiffness.
The analysis group assessed a small group of younger, wholesome volunteers in each supine and seated positions on the identical day. The researchers measured coronary heart charge and blood stress in addition to cfPWV and took measurements thrice in every place. In addition they analyzed the distinction in arterial stiffness markers after a change from one place to the opposite.
Blood stress, arterial stress and coronary heart charge have been usually increased when members have been sitting in comparison with mendacity down. The researchers discovered cfPWV to be a lot increased when seated as properly. Nonetheless, when blood circulation and blood stress between the 2 postures and adjusting the calculations to account for modifications in hydrostatic stress (stress created as a result of gravity), the readings have been way more comparable.
As well as, these findings counsel the activation of the sympathetic nervous system that happens whereas sitting is just not sturdy sufficient to trigger massive will increase in arterial stiffness.
This examine could have necessary implications for prognosis of arterial stiffness and, in flip, the chance of coronary heart illness.
“It’s essential to fastidiously contemplate the topic’s posture throughout [pulse wave velocity] measurements to precisely assess arterial stiffness,” the researchers wrote. “For sufferers who discover it difficult to take care of a completely supine posture … values obtained within the seated place might be appropriately adjusted for [hydrostatic and transmural pressure].”
Extra data:
Marino Karaki et al, The validity of carotid-femoral pulse wave velocity within the seated posture as an index of central arterial stiffness, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (2024). DOI: 10.1152/ajpregu.00073.2024
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Important signal accuracy could depend upon physique place, analysis suggests (2025, February 20)
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