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This Pill-Size Diagnostic Seeks to Prevent Thousands of Esophageal Cancer Deaths

November 26, 2024
in Health
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Esophageal most cancers is among the most dangerous cancers — so why doesn’t the healthcare trade have higher instruments to stop the illness?

Lucid Diagnostics is on a mission to unravel that downside. The corporate — which was launched in 2018 as a subsidiary of medtech firm PAVmed — has developed a fast, office-based check that may detect precancer in folks with heartburn vulnerable to growing esophageal most cancers.

By specializing in stopping esophageal most cancers, Lucid is fulfilling an unmet want, identified CEO Lishan Aklog. On the subject of early detection applications, this most cancers kind has seen considerably much less exercise than different cancers, akin to breast, lung, colon and cervical, he stated.

Lucid’s check for esophageal precancer, known as EsoCheck, is primarily meant for sufferers with gastroesophageal reflux illness (GERD), generally referred to as heartburn or acid reflux disorder. Individuals with GERD are thought of to be at excessive threat for growing esophageal precancer and most cancers, Aklog famous.

“The important thing to stopping 16,000 [annual] most cancers deaths is to not detect it at an early stage. That’s not very efficient as a result of Stage 1 esophageal most cancers has an virtually 50% mortality charge,” he defined. “So as to truly have an effect and stop these deaths, it’s important to choose it up on the precancer stage.”

If a doctor identifies that their affected person has early precancer, they normally simply monitor the affected person with an endoscopy each three years, Aklog stated. If a doctor determines that their affected person has late precancer, the care group normally then performs an endoscopic ablation, a process that destroys the irregular precancer cells earlier than they will progress to most cancers, he added.

Earlier than Lucid’s check, the one means for physicians to determine esophageal precancer was by way of endoscopy, Aklog acknowledged.

Endoscopies usually are not handy, although, he famous — explaining that they’re invasive, require an intravenous anesthetic and normally necessitate time-consuming preparation and restoration.

“Endoscopy has failed as a screening methodology. The lacking hyperlink in all of this — in order that we might truly stop these tragic deaths — was a easy, efficient, outpatient office-based check that may detect a precancerous situation and put folks on surveillance and a therapy program to stop most cancers. And that’s what we have now,” Aklog remarked.

The EsoCheck system — which acquired FDA clearance in 2019 — is the scale of a typical vitamin capsule, and it’s hooked up to a skinny catheter. The system collects cells from a affected person’s esophagus when swallowed, that are then analyzed for genetic markers related to esophageal precancer and most cancers.

The entire strategy of accumulating the pattern takes “a minute or two,” Aklog declared.

There are at the very least 30 million sufferers every year who ought to be examined for esophageal precancer however usually are not, he stated. These are people who find themselves over age 50 and have two threat components — which embody issues like weight problems, smoking, heavy alcohol consumption and power GERD.

The complexity of endoscopies signifies that many physicians fail to suggest them and lots of sufferers choose to not undergo with them — however EsoCheck has the potential to unravel this problem with its comfort, Aklog stated.

He famous that Lucid is the one firm promoting a business expertise that may carry out noninvasive biomarker testing for esophageal precancer.

Aklog additionally stated that he’s optimistic Lucid’s product might be permitted for protection by Medicare and business insurers “fairly shortly.”

Photograph: Lucid Diagnostics



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Tags: cancerDeathsdiagnosticEsophagealPillSizepreventseeksThousands
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