Optimizing naloxone kit distribution to prevent opioid deaths

A brand new research from College of Toronto Engineering researchers factors to sensible methods to forestall deaths from opioid poisoning by optimizing the distribution of naloxone kits.

In a paper revealed within the Canadian Medical Affiliation Journal, Professor Timothy Chan and his staff confirmed that inserting naloxone kits in transit stations may assist make sure that these probably life-saving instruments are current the place they’re most wanted.

The opioid epidemic is a profound public well being disaster, and it is probably not apparent at first how engineering researchers can assist.

In collaboration with docs and different medical professionals, we are able to apply methods from our area – operations analysis and mathematical optimization – to develop new options.”

Professor Timothy Chan, College of Toronto Engineering

Chan and his staff have beforehand collaborated with medical researchers to take a look at the distribution of automated exterior defibrillators, or AEDs, in city areas.

Utilizing pc fashions, they have been in a position to analyze spatial information on previous cardiac arrests. They might then optimize AED placement to maximise the quantity that might be accessible from these places.

“Naloxone kits are considerably analogous to AEDs in that they’ll reverse the results of an opioid poisoning occasion, however provided that they’re out there rapidly, which implies they should be in the precise places,” says Chan.

Of their newest work, Chan and his staff collaborated with emergency physicians and researchers, together with Dr. Brian Grunau and Dr. Jim Christenson at St. Paul’s Hospital in Vancouver, B.C.

They started by analyzing information from greater than 14,000 opioid poisoning incidents that have been recorded by BC Emergency Well being Providers between December 2014 and August 2020 in Metro Vancouver.

They then constructed a pc mannequin that might simulate what number of of these incidents would have taken place inside a 3-minute stroll from a naloxone package, primarily based on a number of distribution methods.

“The primary technique was to take a look at places that have already got free naloxone distribution packages, reminiscent of pharmacies and well being clinics,” says Ben Leung, lead creator on the paper.

Leung constructed the mannequin whereas working as a PhD scholar in Chan’s lab; he’s now a analysis fellow on the Duke Scientific Analysis Institute in Durham, N.C.

“Our second technique was to take a look at chain eating places or comparable companies. And our third technique was to take a look at transit, together with each SkyTrain stations and bus stops.”

Leung’s evaluation confirmed that greater than a 3rd of previous opioid poisonings befell inside about 150 metres of places the place naloxone is being distributed.

Switching to a technique specializing in chain eating places and comparable companies didn’t noticeably enhance protection: relying on what number of totally different chains have been included and what number of kits distributed, protection solely reached a most of about 20%.

However the third technique of leveraging transit stops was essentially the most promising.

“Proper now, there are about 650 places with take-home naloxone distribution packages,” says Leung.

“What we discovered was that if we used transit stops as a substitute, we may get the identical quantity of protection with solely about 60 kits. If we enhance the variety of kits to 1000, we may cowl greater than half of the opioid poisonings that we analyzed.”

Leung factors out that totally different methods can be utilized together to additional enhance protection. He hopes that the insights which were generated by the brand new research will assist public well being officers make higher strategic selections sooner or later.

“There have been a couple of small pilot packages placing naloxone kits in public places, however to our data, that is the primary time anybody has analyzed what large-scale distribution would appear to be utilizing mathematical optimization methods,” he says.

“By presenting these outcomes, I feel we are able to make a powerful case for doing that.”

Chan hopes that these sorts of research can seed broader adjustments as nicely.

“For instance, in Japan, AEDs are extensively out there at merchandising machines,” he says.

“That has led to an affiliation: if somebody is having a cardiac arrest, you mechanically know to go to the closest merchandising machine for an AED.

“If we are able to do one thing comparable for naloxone, it may assist bystanders really feel extra empowered to step in when they’re wanted to avoid wasting lives.”