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Off-the-shelf stem cell therapy for type 1 diabetes yields more positive results

June 21, 2025
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Elizabeth Cooney is a heart problems reporter at STAT, overlaying coronary heart, stroke, and metabolic circumstances. You may attain Liz on Sign at LizC.22.

Twelve folks with kind 1 diabetes who acquired an investigational off-the-shelf stem cell remedy had been capable of produce their very own insulin and preserve wholesome blood glucose ranges for not less than one 12 months, Vertex Prescribed drugs stated Friday. After three months, none of them suffered extreme bouts of low blood sugar. After 12 months, out of the 12 individuals, 10 now not wanted to inject insulin.

The research, introduced Friday on the American Diabetes Affiliation’s scientific assembly and concurrently revealed within the New England Journal of Drugs, updates earlier analysis that adopted these individuals for a shorter time period. All of the individuals acquired a full dose of the remedy, now referred to as zimislecel however beforehand often called VX-880.

Derived from a lab-grown stem cell line meant to distinguish into insulin creators, the remedy is designed to present folks new islet cells that produce insulin, changing their pure counterparts impaired by the illness.

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