Wednesday, June 4, 2025
VISIT ROYALMOK
Agarwood Times
  • Home
  • Agarwood
  • Health
  • Diseases
  • Diet & Fitness
  • Nutrition
  • Sleep Info
  • Meditation
  • Shop
No Result
View All Result
  • Home
  • Agarwood
  • Health
  • Diseases
  • Diet & Fitness
  • Nutrition
  • Sleep Info
  • Meditation
  • Shop
No Result
View All Result
Agarwood Times
No Result
View All Result

Obesity-induced inflammation increases the secretion of extracellular vesicles from adipose tissue

August 19, 2024
in Diseases
Reading Time: 3 mins read
0 0
A A
0
Home Diseases
Share on FacebookShare on Twitter


Obesity-induced inflammation increases the secretion of extracellular vesicles from adipose tissue

Characterization of extracellular vesicles (EVs) from Simpson Golabi Behmel Syndrome (SGBS) cells. Credit score: Journal of Translational Medication (2024). DOI: 10.1186/s12967-024-05249-w

New analysis from the College of Japanese Finland sheds gentle on the mechanisms associating weight problems with irritation by exploring tiny membrane particles, often known as extracellular vesicles, secreted by human adipocytes.

The research discovered that obesity-induced adipose tissue irritation elevated the secretion of extracellular vesicles, which can contribute to the detrimental well being results of weight problems. The findings have been revealed within the Journal of Translational Medication.

When individuals acquire weight, their adipose tissue expands, which regularly results in its irritation, and to insulin resistance. Regular adipose tissue operate is disrupted, and it begins to launch lipids and inflammatory cytokines.

In different phrases, adipose tissue isn’t passive, however it actively communicates with different tissues, and likewise contributes to the pathogenesis of varied ailments and situations.

Latest years have seen the publication of intriguing research suggesting that adipose tissue additionally secretes tiny membrane particles, i.e., extracellular vesicles, which can play a big function in weight problems and in obesity-induced metabolic problems. Nevertheless, earlier research have largely examined extracellular vesicles obtained from adipocytes and adipose tissue of mice.

Visceral adipose tissue secretes extra vesicles than subcutaneous adipose tissue

Extracellular vesicles could be present in all physique fluids, and their discovery has revolutionized our understanding of intracellular communication. In essence, cells use them to convey on the spot messages between cells and to change one another’s operate. Extracellular vesicles secreted by completely different tissues, together with adipose tissue, could also be related to the pathogenesis of varied ailments. Nevertheless, the mechanisms that enhance the secretion of extracellular vesicles from adipocytes haven’t been studied in people earlier than.

The current research confirmed that in weight problems, adipose tissue irritation will increase the secretion of extracellular vesicles from human adipocytes. As well as, the research was the primary to exhibit with statistical certainty that human visceral adipose tissue, i.e., fats accrued within the stomach cavity, secretes extra extracellular vesicles than subcutaneous adipose tissue. The elevated vesicle secretion from visceral adipose tissue was additionally related to a rise in plasma triglyceride ranges.

The researchers used a human-derived adipocyte cell line in addition to adipose tissue samples collected from bariatric surgical procedure sufferers at Kuopio College Hospital and Cattinara Hospital in Trieste.

As well as, the researchers in contrast extracellular vesicles remoted from the plasma of people with regular weight, and from the plasma of bariatric surgical procedure sufferers. The plasma of bariatric surgical procedure sufferers contained the next variety of extracellular vesicles containing adiponectin, which is a mediator produced by adipose tissue.

It is a additional indication of elevated extracellular vesicle secretion from adipose tissue in weight problems. General, the elevated variety of extracellular vesicles within the plasma was related to adipose tissue irritation and with excessive BMI in bariatric surgical procedure sufferers.

The findings present new perception into the operate of adipose tissue, in addition to into the event of novel remedies. There are ample alternatives for additional analysis, as obesity-induced secretion of extracellular vesicles might result in, e.g., irritation and insulin resistance in different tissues they find yourself in.

“Utilizing microscopy, we confirmed, for the primary time, that extracellular vesicles secreted by adipocytes and adipose tissue comprise triglycerides, i.e., fats saved in adipose tissue. Earlier research have recommended that fat contained in extracellular vesicles secreted by adipose tissue may function a supply of vitality for most cancers cells, for instance,” says Doctoral Researcher Johanna Matilainen of the College of Japanese Finland, the primary creator of the research.

Extra data:
Johanna Matilainen et al, Elevated secretion of adipocyte-derived extracellular vesicles is related to adipose tissue irritation and the mobilization of extra lipid in human weight problems, Journal of Translational Medication (2024). DOI: 10.1186/s12967-024-05249-w

Offered by
College of Japanese Finland

Quotation:
Weight problems-induced irritation will increase the secretion of extracellular vesicles from adipose tissue (2024, August 19)
retrieved 19 August 2024
from https://medicalxpress.com/information/2024-08-obesity-inflammation-secretion-extracellular-vesicles.html

This doc is topic to copyright. Aside from any truthful dealing for the aim of personal research or analysis, no
half could also be reproduced with out the written permission. The content material is supplied for data functions solely.



Source link

Tags: adiposeextracellularIncreasesinflammationObesityinducedsecretionTissuevesicles
Previous Post

Less Is More Nutrition

Next Post

5 Tips to Prioritize Self Care

Related Posts

Mother’s obesity linked to child’s heightened hospital admission risk for infection
Diseases

Mother’s obesity linked to child’s heightened hospital admission risk for infection

June 4, 2025
Report highlights evidence, remaining data gaps on vaccines and antibiotic resistance
Diseases

Report highlights evidence, remaining data gaps on vaccines and antibiotic resistance

June 3, 2025
MIS-C patients catch up with controls by most measures within 2 years, data suggest
Diseases

MIS-C patients catch up with controls by most measures within 2 years, data suggest

June 4, 2025
U.S. Global Health Legislation Tracker
Diseases

U.S. Global Health Legislation Tracker

June 4, 2025
Large-scale immunity profiling grants insights into flu virus evolution
Diseases

Large-scale immunity profiling grants insights into flu virus evolution

June 3, 2025
Antibody-drug conjugate shows promising safety and response rates for patients with rare blood cancer
Diseases

Antibody-drug conjugate shows promising safety and response rates for patients with rare blood cancer

June 3, 2025
Next Post
5 Tips to Prioritize Self Care

5 Tips to Prioritize Self Care

Top 7 Farmers Market Finds for Fall

Top 7 Farmers Market Finds for Fall

Is It Bad to Eat the Same Thing Every Day?

Is It Bad to Eat the Same Thing Every Day?

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

RECOMMENDED

MIS-C patients catch up with controls by most measures within 2 years, data suggest
Diseases

MIS-C patients catch up with controls by most measures within 2 years, data suggest

by admin
June 4, 2025
0

Two years after hospitalization for multisystem inflammatory syndrome in kids (MIS-C), most sufferers' neurologic and psychological check scores had been...

Astellas Stays Competitive in Hot Gut Cancer Target, Paying 0M to License Evopoint Drug

Astellas Stays Competitive in Hot Gut Cancer Target, Paying $130M to License Evopoint Drug

May 31, 2025
🔥This Environment Topic is Key for UPSC Prelims 2025—Don’t Miss Out!

🔥This Environment Topic is Key for UPSC Prelims 2025—Don’t Miss Out!

May 30, 2025
BMS Buys Into BioNTech Bispecific Antibody, Putting Up .5B to Collaborate in Multiple Cancers

BMS Buys Into BioNTech Bispecific Antibody, Putting Up $1.5B to Collaborate in Multiple Cancers

June 3, 2025
Report highlights evidence, remaining data gaps on vaccines and antibiotic resistance

Report highlights evidence, remaining data gaps on vaccines and antibiotic resistance

June 3, 2025
Healthy Tuscan Farro & White Bean Veggie Burgers

Healthy Tuscan Farro & White Bean Veggie Burgers

May 31, 2025
Facebook Twitter Instagram Youtube RSS
Agarwood Times

Stay informed with the latest news, articles, and insights on agarwood cultivation, history, sustainability, and more. Explore the timeless allure of agarwood and deepen your understanding of this extraordinary natural resource.

CATEGORIES

  • Agarwood
  • Diet & Fitness
  • Diseases
  • Health
  • Meditation
  • Nutrition
  • Sleep Info
  • Uncategorized
No Result
View All Result

SITEMAP

  • About us
  • Advertise With Us
  • Disclaimer
  • Privacy Policy
  • DMCA
  • Cookie Privacy Policy
  • Terms and Conditions
  • Contact us

Copyright © 2024 Agarwood Times.
Agarwood Times is not responsible for the content of external sites.

No Result
View All Result
  • Home
  • Agarwood
  • Health
  • Diseases
  • Diet & Fitness
  • Nutrition
  • Sleep Info
  • Meditation
  • Shop
VISIT ROYALMOK

Copyright © 2024 Agarwood Times.
Agarwood Times is not responsible for the content of external sites.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In