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Novo Nordisk Adds Obesity and Diabetes to AI Drug Research Pact With Flagship’s Valo Health

January 8, 2025
in Health
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Novo Nordisk’s collaboration with synthetic intelligence startup Valo Well being has targeted on growing new medicine for heart problems. The pharmaceutical large likes what it’s seen to this point, and it’s now committing $190 million to increase the alliance to extra cardiometabolic problems, together with weight problems and sort 2 diabetes.

The sum introduced Wednesday encompasses an upfront cost, fairness funding, and a possible near-term cost for a milestone that was not disclosed. The preliminary settlement inked in 2023 spanned as much as 11 heart problems applications. Lexington, Massachusetts-based Valo acquired $60 million up entrance and was in line for as a lot as $2.7 billion in milestone funds. The alliance now spans 20 applications. Milestone funds within the expanded pact might attain as much as $4.6 billion.

Whereas Novo Nordisk has established a robust place in metabolic illness with the GLP-1 agonist semaglutide, marketed as Ozempic for sort 2 diabetes and Wegovy for weight problems, the pharmaceutical large has additionally invested within the R&D of next-generation medicines that might provide higher tolerability and even perhaps better weight reduction. One of many firm’s prime prospects is CagriSema, a mix of semaglutide with cagrilintide. Final month the once-weekly injection posted statistically important Section 3 outcomes. However shares of Novo Nordisk nonetheless took a success because the magnitude of weight reduction was beneath expectations.

Novo Nordisk has turned to enterprise growth to construct its pipeline of metabolic medicines. These offers carry drug candidates in oral formulations that might increase the sphere to new targets. Particular targets coated by Novo Nordisk’s settlement with Valo stay undisclosed, however the corporations say the collaboration has already led to identification of “a number of novel targets” with the potential to result in differentiated cardiometabolic medicine. They add that work is underway on a number of small molecule applications in preclinical growth.

Valo launched in 2020, fashioned and initially financed by Flagship Pioneering, a agency that kinds and invests in new startups based mostly on platform applied sciences. The AI-driven simulations from its know-how, referred to as Opal Computational Platform, predict properties akin to the security and efficacy of a possible drug. Valo takes a human-centric method to AI, CEO Brian Alexander mentioned in an e-mail. The corporate analyzes real-world human information to establish novel drug targets. Valo additionally makes use of human fashions to quickly uncover and develop small molecules that hit these targets.

Opal is indication agnostic, however Valo has invested considerably in cardiometabolic illness as certainly one of its focus areas, Alexander mentioned. When Valo was getting ready to go public in a SPAC merger, the corporate mentioned it had 17 applications that spanned most cancers and neurodegenerative ailments.

Valo is just not at present disclosing pipeline particulars. Nevertheless, OPL-0401, a diabetic retinopathy drug candidate that was certainly one of its most superior applications, didn’t meet main or secondary endpoints, Valo disclosed on New 12 months’s Eve. That in-licensed molecule was not produced by Opal. The corporate mentioned it will droop this system’s growth and deal with leveraging Opal to develop new medicines. That features medicines coated by the expanded Novo Nordisk pact.

“Our expertise with the Novo Nordisk partnership up to now has demonstrated clear proof of each the platform’s technological capabilities in addition to the human-centric method to information and methods of working internally and with companions to ship on new medicines in CVM (cardiovascular medication), however not restricted to CVM,” Alexander mentioned. “This growth into weight problems and sort 2 diabetes is validating of that have.”

Photograph: Liselotte Sabroe/Scanpix Denmark/AFP, through Getty Photographs



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Tags: addsdiabetesDrugFlagshipsHealthNordiskNovoObesityPactResearchValo
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