Thursday, June 5, 2025
VISIT ROYALMOK
Agarwood Times
  • Home
  • Agarwood
  • Health
  • Diseases
  • Diet & Fitness
  • Nutrition
  • Sleep Info
  • Meditation
  • Shop
No Result
View All Result
  • Home
  • Agarwood
  • Health
  • Diseases
  • Diet & Fitness
  • Nutrition
  • Sleep Info
  • Meditation
  • Shop
No Result
View All Result
Agarwood Times
No Result
View All Result

New study shows how salmonella tricks gut defenses to cause infection

November 17, 2024
in Diseases
Reading Time: 4 mins read
0 0
A A
0
Home Diseases
Share on FacebookShare on Twitter


Salmonella enteritidis

Colorized SEM (scanning electron micrograph) of the foodborne pathogen Salmonella enteritidis. Blue is progress medium. Image is coloured in false colours for instance distinction. Picture by Jean Guard, ARS. Credit score: U.S. Division of Agriculture/public area

A brand new UC Davis Well being examine has uncovered how Salmonella micro organism, a significant reason behind meals poisoning, can invade the intestine even when protecting micro organism are current. The analysis, revealed within the Proceedings of the Nationwide Academy of Sciences, explains how the pathogen methods the intestine setting to flee the physique’s pure defenses.

The digestive system is dwelling to trillions of micro organism, lots of which produce short-chain fatty acids (SCFAs) that assist battle dangerous pathogens. However Salmonella manages to develop and unfold within the intestine, though these protecting compounds are current. The examine asks: How does Salmonella get round this protection?

“We knew that Salmonella invades the small gut, though it isn’t its main web site of replication. The colon is,” stated the lead writer of the examine Andreas Bäumler. Bäumler is a UC Davis distinguished professor and vice chair of analysis within the Division of Medical Microbiology and Immunology.

Bäumler and his crew found that the reply lies in how the pathogen modifications the intestine’s nutrient stability. When Salmonella enters the small gut, it causes irritation within the intestine lining and disrupts the conventional absorption of amino acids from meals. This creates an imbalance in vitamins within the intestine.

The imbalance provides Salmonella the assets it must survive and multiply within the massive gut (colon), the place useful micro organism normally curb its progress. The examine confirmed that salmonella causes irritation within the small gut so as to derive vitamins that gas its replication within the colon.

Salmonella alters intestine nutrient setting to outlive

Utilizing a mouse mannequin, the crew appeared intently at how Salmonella modified the chemical make-up of the intestine. They traced amino acid absorption within the small and huge intestines.

They discovered that in mice that have been contaminated with Salmonella, there was much less absorption of amino acids into the blood. In actual fact, two amino acids, lysine and ornithine, turned extra ample within the intestine after an infection. These amino acids helped Salmonella survive by stopping the growth-inhibiting results of SCFAs. They did this by restoring Salmonella’s acidity (pH) stability, permitting the pathogen to bypass the microbiota’s defenses.

“Our findings present that Salmonella has a intelligent means of adjusting the intestine’s nutrient setting to its benefit. By making it tougher for the physique to soak up amino acids within the ileum, Salmonella creates a extra favorable setting for itself within the massive gut,” Bäumler stated.

Within the examine, the crew confirmed that Salmonella makes use of its personal virulence components (illness inflicting molecules) to activate enzymes that break down key amino acids like lysine. This helps the pathogen keep away from the SCFAs’ protecting results and develop extra simply within the intestine.

New insights might result in higher intestine an infection remedies

The brand new insights probably clarify how the intestine setting modifications throughout inflammatory bowel issues , resembling Crohn’s illness and ulcerative colitis, and will result in higher remedies for intestine infections. By understanding how Salmonella modifications the intestine setting, researchers hope to develop new methods to guard the intestine microbiota and forestall these infections.

“This analysis makes use of a extra holistic method to learning intestine well being. It not solely provides us a greater understanding of how Salmonella works, but in addition highlights the significance of sustaining a wholesome intestine microbiota,” stated Lauren Radlinski, the examine’s first writer and postdoctoral fellow within the Bäumler Lab. “Our findings might result in new remedies that assist assist the microbiota throughout an infection.”

The examine’s outcomes might encourage future remedies, together with probiotics or dietary plans designed to strengthen the physique’s pure defenses towards dangerous pathogens.

“By studying how a pathogen manipulates the host’s system, we will uncover methods to spice up the host’s pure defenses,” Radlinski stated.

Co-authors of the examine are Andrew Rogers, Lalita Bechtold, Hugo Masson, Henry Nguyen, Anaïs B. Larabi, Connor Tiffany, Thaynara Parente de Carvalho and Renée Tsolis of UC Davis.

Extra data:
Lauren C. Radlinski et al, Salmonella virulence components induce amino acid malabsorption within the ileum to advertise ecosystem invasion of the big gut, Proceedings of the Nationwide Academy of Sciences (2024). DOI: 10.1073/pnas.2417232121

Quotation:
New examine reveals how salmonella methods intestine defenses to trigger an infection (2024, November 16)
retrieved 16 November 2024
from https://medicalxpress.com/information/2024-11-salmonella-gut-defenses-infection.html

This doc is topic to copyright. Other than any honest dealing for the aim of personal examine or analysis, no
half could also be reproduced with out the written permission. The content material is supplied for data functions solely.



Source link

Tags: DefensesGutInfectionSalmonellashowsStudytricks
Previous Post

Study Shows Probiotics & Fiber Improve Metabolic Health

Next Post

Weekly Horoscope For November 18-24, 2024, From The AstroTwins

Related Posts

Baby’s microbiome may protect against later childhood viral infection
Diseases

Baby’s microbiome may protect against later childhood viral infection

June 5, 2025
Maternal obesity linked to increase in childhood infections
Diseases

Maternal obesity linked to increase in childhood infections

June 5, 2025
‘Helping people survive’: how creating a hip-hop album saved incarcerated artists | Hip-hop
Diseases

‘Helping people survive’: how creating a hip-hop album saved incarcerated artists | Hip-hop

June 4, 2025
Mother’s obesity linked to child’s heightened hospital admission risk for infection
Diseases

Mother’s obesity linked to child’s heightened hospital admission risk for infection

June 4, 2025
Report highlights evidence, remaining data gaps on vaccines and antibiotic resistance
Diseases

Report highlights evidence, remaining data gaps on vaccines and antibiotic resistance

June 3, 2025
MIS-C patients catch up with controls by most measures within 2 years, data suggest
Diseases

MIS-C patients catch up with controls by most measures within 2 years, data suggest

June 4, 2025
Next Post
Weekly Horoscope For November 18-24, 2024, From The AstroTwins

Weekly Horoscope For November 18-24, 2024, From The AstroTwins

Heat Healer Energy Mat Review + Save 25% Sitewide

Heat Healer Energy Mat Review + Save 25% Sitewide

New microfluidic device shows tumor shape predicts cancer aggressiveness

New microfluidic device shows tumor shape predicts cancer aggressiveness

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

RECOMMENDED

Norovirus vaccine produces mucosal immunity in phase 2b trial
Diseases

Norovirus vaccine produces mucosal immunity in phase 2b trial

by admin
May 30, 2025
0

kovop58/iStock Receiving a previous COVID-19 vaccine didn't stop the immune system from producing protecting responses to both Delta or Omicron...

Solicitor general urges Supreme Court not to review Oklahoma law on PBMs

Solicitor general urges Supreme Court not to review Oklahoma law on PBMs

May 30, 2025
Kura Oncology Drug’s Data at ASCO Support FDA Filing Now Under Priority Review for Leukemia

Kura Oncology Drug’s Data at ASCO Support FDA Filing Now Under Priority Review for Leukemia

June 4, 2025
Viz.ai, Novartis partner for AI-powered care for patients with cancer

Viz.ai, Novartis partner for AI-powered care for patients with cancer

June 3, 2025
A tragic paradox, Gilead updates, and lots of Pfizer news

A tragic paradox, Gilead updates, and lots of Pfizer news

June 1, 2025
Strong stocks in market #stocksfortomorrow #stockstobuy #strongstock #shortvideo #shorts

Strong stocks in market #stocksfortomorrow #stockstobuy #strongstock #shortvideo #shorts

June 3, 2025
Facebook Twitter Instagram Youtube RSS
Agarwood Times

Stay informed with the latest news, articles, and insights on agarwood cultivation, history, sustainability, and more. Explore the timeless allure of agarwood and deepen your understanding of this extraordinary natural resource.

CATEGORIES

  • Agarwood
  • Diet & Fitness
  • Diseases
  • Health
  • Meditation
  • Nutrition
  • Sleep Info
  • Uncategorized
No Result
View All Result

SITEMAP

  • About us
  • Advertise With Us
  • Disclaimer
  • Privacy Policy
  • DMCA
  • Cookie Privacy Policy
  • Terms and Conditions
  • Contact us

Copyright © 2024 Agarwood Times.
Agarwood Times is not responsible for the content of external sites.

No Result
View All Result
  • Home
  • Agarwood
  • Health
  • Diseases
  • Diet & Fitness
  • Nutrition
  • Sleep Info
  • Meditation
  • Shop
VISIT ROYALMOK

Copyright © 2024 Agarwood Times.
Agarwood Times is not responsible for the content of external sites.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In