Optoelectronically lively bioink composition and printing. (A) Schematic of bioprinting combining μ-solar cells and GelMA after which seeding with CMs. (B) Images of the bioprinting course of (i, ii, and iii) of the optoelectronic coronary heart (atria and ventricles) together with a aspect view. Inset reveals the mannequin coronary heart with the printed portion in blue and the rest of the guts in grey. (C) Instance of in vivo implantation of a printed optoelectronically lively tissue and correction of arrhythmic beating. Credit score: Science Advances (2025). DOI: 10.1126/sciadv.adt7210
Researchers from Mass Basic Brigham and collaborating establishments have developed a non-invasive method to control cardiac tissue exercise through the use of gentle to stimulate an modern ink integrated into bioprinted tissue. Their objective is to develop a method that can be utilized to restore the guts. Their findings in preclinical fashions, revealed in Science Advances, present the transformative potential of non-invasive therapeutic strategies to regulate electrically lively tissues.
“We confirmed for the primary time that with this optoelectronically lively ink, we will print scaffolds that enable distant management of engineered coronary heart tissues,” stated co-corresponding writer Y. Shrike Zhang, Ph.D., of the Division of Engineering in Medication at Brigham and Ladies’s Hospital, a founding member of the Mass Basic Brigham well being care system. “This method paves the way in which for non-invasive gentle stimulation, tissue regeneration, and host integration capabilities in cardiac remedy and past.”
Three-dimensional bioprinted tissues composed of cells and different body-compatible supplies are a strong rising software to restore broken coronary heart tissue. However most bioprinted tissues can not generate the mandatory electrical exercise for mobile perform. They need to as an alternative depend on invasive wire and electrode placement to regulate coronary heart exercise, which might harm physique tissues.
Zhang and his colleagues addressed this limitation by infusing the bioprinted tissue with the “optoelectronically lively” ink that may be remotely stimulated by gentle to generate electrical exercise in these tissues. The authors additionally confirmed that these new, dynamic engineered tissues can synchronize with and speed up the guts fee when stimulated by gentle in preclinical fashions.
“Now that we have now established the proof-of-concept for this expertise, we’re shifting our efforts in direction of understanding the way it may promote long-term tissue regeneration and integrating it seamlessly inside the coronary heart’s biology,” stated Zhang.
Extra data:
Faheem Ershad et al, Bioprinted optoelectronically lively cardiac tissues, Science Advances (2025). DOI: 10.1126/sciadv.adt7210
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Mass Basic Brigham
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Gentle-activated ink developed to remotely management cardiac tissue to restore the guts (2025, January 24)
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