Sunday, June 8, 2025
VISIT ROYALMOK
Agarwood Times
  • Home
  • Agarwood
  • Health
  • Diseases
  • Diet & Fitness
  • Nutrition
  • Sleep Info
  • Meditation
  • Shop
No Result
View All Result
  • Home
  • Agarwood
  • Health
  • Diseases
  • Diet & Fitness
  • Nutrition
  • Sleep Info
  • Meditation
  • Shop
No Result
View All Result
Agarwood Times
No Result
View All Result

Ketogenic diet linked to gut microbes and seizure reduction in epileptic children

November 7, 2024
in Health
Reading Time: 4 mins read
0 0
A A
0
Home Health
Share on FacebookShare on Twitter


New research finds particular intestine micro organism and metabolites, like plasmalogens, might play a key position within the ketogenic weight loss program’s anti-seizure results for drug-resistant epilepsy.

Examine: Affiliation between seizure discount throughout ketogenic weight loss program remedy of epilepsy and modifications in circulatory metabolites and intestine microbiota composition. Picture Credit score: New Africa/Shutterstock.com

In a latest research revealed within the eBioMedicine, a bunch of researchers investigated the associations between intestine microbiota, serum metabolome, and seizure discount in youngsters with drug-resistant epilepsy (neurological dysfunction) following three months on a ketogenic weight loss program (KD) (a excessive fats, enough protein, and low carbohydrate weight loss program).

Background

Epilepsy is impacting over 50 million people globally, with almost one-third of sufferers remaining drug-resistant regardless of quite a few antiseizure medicines (ASMs). Pharmaco-resistant epilepsy is characterised by the lack to realize seizure freedom after sufficient trials of two appropriate ASMs.

The KD dietary remedy is a acknowledged remedy for kids with pharmaco-resistant epilepsy, leading to over 50% of individuals experiencing a big discount in seizures.

Whereas KD induces varied systemic metabolic modifications, together with elevated ketone ranges, the exact mechanisms behind its anti-seizure results stay unclear, necessitating additional analysis.

In regards to the research

The analysis was carried out on the Neuropediatric Division of Astrid Lindgren Kids’s Hospital, Karolinska Hospital, involving youngsters identified with epilepsy who had been handled on the Epilepsy Outpatient Clinic.

As a result of their resistance to anti-seizure medicines, a KD was initiated for eligible individuals aged 2 to 17 years with pharmaco-resistant epilepsy. Exclusion standards included latest antibiotic or probiotic use. A complete of 14 sufferers met the inclusion standards. The efficacy of the KD was evaluated by monitoring modifications in seizure frequency, which had been recorded every day by mother and father or caregivers on seizure calendars.

Baseline seizure frequency was in comparison with that recorded three months after commencing the weight loss program, and individuals had been categorised as responders or non-responders based mostly on a 50% seizure discount threshold.

Every kid’s KD was personalized by a specialised dietitian, with a stepwise improve within the fat-to-carbohydrate and protein ratio, sometimes reaching the optimum ratio inside 3 to six weeks.

Blood samples had been collected pre- and post-KD for glucose and beta-hydroxybutyrate evaluation, alongside serum and fecal samples for metabolomic and microbiome research. Moral approval was secured, and knowledgeable consent was obtained from guardians and, when doable, the kids.

Examine outcomes

The research cohort comprised 14 youngsters identified with epilepsy, together with 9 ladies and 5 boys, with a median age of 8.0 years on the initiation of the KD. Epilepsy onset occurred at a median age of 0.6 years, with 10 of the 14 individuals experiencing signs earlier than their first birthday.

Seizure sorts and aetiologies had been categorized in response to the Worldwide League In opposition to Epilepsy (ILAE) pointers, revealing that the majority youngsters exhibited a number of seizure sorts, with a median of two.0 varieties per affected person.

The predominant seizure sorts had been generalized tonic-clonic seizures and focal seizures with impaired consciousness. Previous to the KD, individuals had trialed a median of six ASMs. On the onset of the weight loss program, the variety of concomitant ASMs diversified from one to 4, with a median of two.

Essentially the most continuously used ASMs included valproic acid and clobazam. Whereas the objective was to keep up steady ASM dosages for the preliminary three months of the KD, some changes had been vital as a consequence of opposed results, together with reductions in doses of topiramate and valproate for a number of youngsters.

On the three-month mark on the KD, the imply ratio of fat to carbohydrates and proteins was 3.5 (±SD 0.4), ranging between 3:1 and 4:1. Half of the individuals (seven youngsters) had been categorized as responders, demonstrating a seizure discount of fifty% or extra.

The median degree of beta-hydroxybutyrate (β-OHB) amongst responders was 5.2 mmol/L, in comparison with 4.9 mmol/L in non-responders, which was not statistically vital.

The evaluation of metabolomic profiles highlighted vital modifications associated to dietary remedy. Variance was largely attributed to the dietary intervention, with notable variations between responders and non-responders.

A complete of 995 metabolites had been detected, with 345 displaying vital modifications attributed to the KD. Amongst these, ketone our bodies reminiscent of 3-hydroxybutyrate and acetoacetate elevated considerably, whereas glucose ranges decreased as anticipated. Moreover, metabolic pathway analyses revealed eight considerably altered pathways, primarily involving fatty acids.

Conclusions

To summarize, this investigation reveals vital alterations in metabolites, together with lipid pathways and nutritional vitamins, linked to intestine microbiota and seizure response. Notably, 4 plasmalogens correlated positively with seizure discount, whereas propionate and thymol sulfate had been recognized as helpful metabolites.

Conversely, sure diacylglycerols and gamma-glutamyl amino acids confirmed adverse correlations with seizure frequency.

4 intestine microbial species, particularly from the genus Alistipes, positively correlated with helpful metabolites, whereas particular strains of Escherichia coli and infant-type Bifidobacteria negatively impacted seizure discount, highlighting the significance of intestine microbiota steadiness throughout KD in epilepsy remedy.



Source link

Tags: childrenDietepilepticGutKetogenicLinkedmicrobesReductionseizure
Previous Post

Agarwood business || Agarwood farming in Pakistan || Why Agarwood Is So Expensive || Javed Kamyana

Next Post

Drinking Water, Losing Weight

Related Posts

RFK Jr.’s chronic disease agency budget documents released
Health

RFK Jr.’s chronic disease agency budget documents released

June 8, 2025
New rules for cosmetic injectables aim to make the industry safer. Will they work?
Health

New rules for cosmetic injectables aim to make the industry safer. Will they work?

June 7, 2025
Preeclampsia linked to long-term cerebrovascular damage and worsened stroke outcomes
Health

Preeclampsia linked to long-term cerebrovascular damage and worsened stroke outcomes

June 7, 2025
Knee Stem Cell Injection Gains Attention as an Innovative
Health

Knee Stem Cell Injection Gains Attention as an Innovative

June 7, 2025
NIH cuts: Trump budget slashes grants, training, research centers
Health

NIH cuts: Trump budget slashes grants, training, research centers

June 7, 2025
Serve You Rx Adds 2 Stelara Biosimilars to Formulary to Help Patients Save Costs
Health

Serve You Rx Adds 2 Stelara Biosimilars to Formulary to Help Patients Save Costs

June 7, 2025
Next Post
Drinking Water, Losing Weight

Drinking Water, Losing Weight

When Hormones Go Haywire: Start Here

When Hormones Go Haywire: Start Here

Social media likes and comments linked to young men’s obsession with perfect pecs and a six-pack

Social media likes and comments linked to young men's obsession with perfect pecs and a six-pack

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

RECOMMENDED

Rosemary Whole Grain Seed Crackers
Diet & Fitness

Rosemary Whole Grain Seed Crackers

by admin
June 2, 2025
0

Flip to the ability of entire grains, seeds, and herbs to create probably the most flavorful, wholesome crackers conceivable. In...

U.S. Global Health Legislation Tracker

U.S. Global Health Legislation Tracker

June 4, 2025
‘Helping people survive’: how creating a hip-hop album saved incarcerated artists | Hip-hop

‘Helping people survive’: how creating a hip-hop album saved incarcerated artists | Hip-hop

June 4, 2025
Kura Oncology Drug’s Data at ASCO Support FDA Filing Now Under Priority Review for Leukemia

Kura Oncology Drug’s Data at ASCO Support FDA Filing Now Under Priority Review for Leukemia

June 4, 2025
Statins may reduce risk of death by 39% for patients with life-threatening sepsis, large study finds

Statins may reduce risk of death by 39% for patients with life-threatening sepsis, large study finds

June 6, 2025
4-Week Healthy Summer Meal Plan With Grocery List

4-Week Healthy Summer Meal Plan With Grocery List

June 6, 2025
Facebook Twitter Instagram Youtube RSS
Agarwood Times

Stay informed with the latest news, articles, and insights on agarwood cultivation, history, sustainability, and more. Explore the timeless allure of agarwood and deepen your understanding of this extraordinary natural resource.

CATEGORIES

  • Agarwood
  • Diet & Fitness
  • Diseases
  • Health
  • Meditation
  • Nutrition
  • Sleep Info
  • Uncategorized
No Result
View All Result

SITEMAP

  • About us
  • Advertise With Us
  • Disclaimer
  • Privacy Policy
  • DMCA
  • Cookie Privacy Policy
  • Terms and Conditions
  • Contact us

Copyright © 2024 Agarwood Times.
Agarwood Times is not responsible for the content of external sites.

No Result
View All Result
  • Home
  • Agarwood
  • Health
  • Diseases
  • Diet & Fitness
  • Nutrition
  • Sleep Info
  • Meditation
  • Shop
VISIT ROYALMOK

Copyright © 2024 Agarwood Times.
Agarwood Times is not responsible for the content of external sites.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In