Immunotherapy yields complete response in stage IV lung cancer

A brand new case report was printed in Oncoscience (Quantity 11) on October 8, 2024, entitled, “Full and long-lasting response to immunotherapy in a stage IV non-small cell lung most cancers with mind metastasis.”

As highlighted within the summary of this report, roughly 20% of lung most cancers sufferers have mind metastases at prognosis, which is related to a worse prognosis and negatively impacts high quality of life. The emergence of recent systemic remedy choices, resembling immune checkpoint inhibitors (ICI) and focused therapies, has modified the prognosis for stage IV lung most cancers sufferers. Nevertheless, the affect of remedy sequencing-;each native and systemic-;in sufferers with stage IV lung most cancers and mind metastases stays unclear.

Researchers Mafalda Costa and Helena Magalhães from the Division of Medical Oncology, Hospital Pedro Hispano in Matosinhos, Portugal current the case of a 51-year-old man recognized with stage IV non-small cell lung most cancers (NSCLC) and mind metastasis. After present process entire mind radiotherapy (WBRT), the affected person achieved each intracranial and extracranial full response following second-line remedy with an immune checkpoint inhibitor. At the moment, he has an total survival of 87 months and a progression-free survival of 73 months, sustaining an optimum high quality of life.

“We hypothesized that remedy sequencing of WBRT and immunotherapy might clarify this surprising final result.”