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How experience shapes hippocampal place cell activity to create flexible cognitive maps

April 25, 2025
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Exploring how experience influences the encoding of information by hippocampal CA1 place cells

Balanced goal- and space-referenced spatial coding in a well-recognized atmosphere. Credit score: Qian, Li & Magee. (Nature Neuroscience, 2025).

The mammalian mind is understood to supply psychological representations of the spatial atmosphere, often known as cognitive maps, that assist people and animals navigate their environment. A subpopulation of neurons within the CA1 space of the hippocampus, that are known as place cells (PCs), have been discovered to turn out to be energetic when animals go to particular locations or places of their atmosphere.

The activation of those cells was beforehand linked to the encoding of space- and goal-related info, which was predicted to assist the creation of cognitive maps. Whereas quite a few previous research explored the perform of PCs and their contribution to the creation of cognitive maps, the position of expertise in shaping the creation of those maps has not but been elucidated.

Researchers at Baylor Faculty of Drugs lately shed new gentle on the mechanisms by means of which expertise might affect the encoding of data by PCs. Their findings, printed in Nature Neuroscience, counsel that experiences produce an adjustment of synaptic enter within the mouse mind, which in flip impacts the exercise of PCs, enabling the manufacturing of versatile cognitive maps.

“Hippocampal CA1 PCs encode each space- and goal-referenced info to assist a cognitive map,” wrote Fish Kunxun Qian, Yiding Li and Jeffrey C. Magee of their paper. “The mechanism of this referencing and the position of expertise stay poorly understood. Right here we longitudinally recorded PC exercise whereas head-fixed mice carried out a spatial studying process on a treadmill.”

Basically, Qian, Li and Magee recorded the exercise of PCs within the hippocampus, particularly within the CA1 space, throughout the mind of twenty-two grownup mice as they carried out a spatial studying process. The recordings have been collected utilizing two methods: two-photon imaging and in vivo intracellular recording by way of an implanted electrode.

“In a well-recognized atmosphere, the CA1 illustration consisted of PCs that have been referenced to both particular spatial places or a reward objective in roughly equal proportions,” wrote Qian, Li and Magee. “Nonetheless, the CA1 illustration turned predominately goal-referenced upon publicity to a novel atmosphere, as space-referenced PCs adaptively switched reference frames.”

The recordings collected by this staff of researchers counsel that when mice begin navigating a brand new atmosphere, the representations produced by place cells within the CA1 area of their hippocampus turn out to be more and more goal-oriented. This implies that the animals’ expertise influences the creation of cognitive maps, which be sure that these maps finest help them in finishing spatial duties and reaching their objectives.

“Intracellular membrane potential recordings revealed that particular person CA1 neurons concurrently acquired each space- and goal-referenced synaptic inputs, and the ratio of those inputs was correlated with particular person PC referencing,” wrote Qian, Li and Magee. “Moreover, behavioral timescale synaptic plasticity formed PC referencing. Collectively, these outcomes counsel that experience-dependent adjustment of synaptic enter shapes PC referencing to assist a versatile cognitive map.”

Total, the latest findings gathered by Qian, Li and Magee counsel that in mice, the adjustment of cognitive maps primarily based on expertise can not less than partly be defined by the dynamic reorganization of synaptic inputs. Future research might additional take a look at this speculation and validate the staff’s findings, bettering the current understanding of the neural processes supporting experience-based spatial studying and navigation.

Extra info:
Fish Kunxun Qian et al, Mechanisms of experience-dependent place-cell referencing in hippocampal space CA1, Nature Neuroscience (2025). DOI: 10.1038/s41593-025-01930-5.

© 2025 Science X Community

Quotation:
How expertise shapes hippocampal place cell exercise to create versatile cognitive maps (2025, April 25)
retrieved 25 April 2025
from https://medicalxpress.com/information/2025-04-hippocampal-cell-flexible-cognitive.html

This doc is topic to copyright. Other than any truthful dealing for the aim of personal examine or analysis, no
half could also be reproduced with out the written permission. The content material is offered for info functions solely.



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