Girls that suffer from endometriosis have an elevated threat of untimely and early menopause, each naturally and surgically, College of Queensland researchers have discovered.
A complete worldwide research discovered girls with endometriosis are at 7 instances the chance of surgical menopause (involving the elimination of each ovaries) and face a better threat of untimely menopause (earlier than age 40) or early menopause (between ages 40-44).
Dr. Hsin-Fang Chung, from UQ’s College of Public Well being, mentioned whereas it was recognized that endometriosis and its remedy can cut back egg high quality and amount, analysis on its impact on the timing of menopause was restricted.
We discovered surgical menopause occurred, on common,19 months earlier in girls with endometriosis, whereas pure menopause occurred 5 months earlier.
Girls with endometriosis are twice as prone to expertise surgical menopause underneath the age of 40, or 1.4 instances extra prone to have pure menopause earlier than 40.”
Dr. Hsin-Fang Chung, UQ’s College of Public Well being
Senior creator, Professor Gita Mishra, mentioned it was already recognized early and surgical menopause have been associated to antagonistic outcomes resembling heart problems and untimely dying.
“Stopping or managing early or medically induced menopause requires a complete understanding of its underlying causes and proactive measures to deal with the long-term well being dangers related to it,” Professor Mishra mentioned.
The research – which analysed knowledge from almost 280,000 girls in Australia, the UK, Sweden and Japan between 1996 and 2022 – is the most important to look at the sort and timing of menopause in girls with endometriosis.
The analysis is a part of InterLACE, a global collaboration analyzing girls’s reproductive well being and persistent illness throughout their lifetime.
Endometriosis is a persistent and infrequently debilitating inflammatory illness, affecting 1 in 7 Australian girls, the place tissue just like the liner of the womb grows in different elements of the physique.
Dr. Chung mentioned she hoped the proof would inform updates to endometriosis administration pointers, emphasising the significance of long-term monitoring of the situation.
“Girls with endometriosis needs to be conscious that they could be at elevated threat of early or induced menopause, go to their GP frequently to examine for persistent illness threat elements, and give attention to prevention methods,” she mentioned.
Dr. Chung’s subsequent step is to analysis the influence of endometriosis on long-term persistent illness dangers.
The findings shall be offered on the sixteenth World Congress on Endometriosis in Sydney later this month.
The analysis is revealed in Human Copy.
Supply:
The College of Queensland
Journal reference:
Chung, H.-F., et al. (2025). Affiliation between endometriosis and kind and age of menopause: a pooled evaluation of 279 948 girls from 5 cohort research. Human Copy. doi.org/10.1093/humrep/deaf068.
