CHICAGO — Novo Nordisk’s next-generation weight problems injection concentrating on the amylin hormone confirmed substantial weight reduction in an early research, however comparable efficacy throughout totally different doses and excessive charges of unintended effects increase questions on which dose Novo will pursue going ahead.
Within the Section 1/2 research testing the drug, referred to as amycretin, sufferers on the very best dose of 60 mg misplaced on common 24.3% of their weight at 36 weeks, whereas these on placebo misplaced 1.1%, in line with outcomes revealed Friday within the Lancet that can even be offered on the American Diabetes Affiliation convention. These outcomes counsel amycretin could possibly be more practical than different medication available on the market.
In one other a part of the research testing 20-mg, 5-mg, and 1.25-mg doses of amycretin, sufferers additionally skilled substantial weight reduction, however with overlapping weight-loss curves. The discovering is uncommon since researchers usually count on a dose-dependent impact, the place sufferers on larger doses lose extra weight sooner.
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