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Automated insulin delivery improves glycemic control of type 2 diabetes in randomized trial

March 22, 2025
in Diseases
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type 2 diabetes

Credit score: Pixabay/CC0 Public Area

Jaeb Heart for Well being Analysis performed a randomized managed trial evaluating the influence of automated insulin supply (AID) in adults with insulin-treated kind 2 diabetes. AID considerably lowered glycated hemoglobin (HbA1c) ranges and improved glucose management in comparison with normal insulin remedy with steady glucose monitoring (CGM).

AID remedy resulted in a imply HbA1c discount of 0.9 proportion factors over 13 weeks, whereas the management group skilled a 0.3 proportion level discount.

Automated insulin supply methods have demonstrated advantages for sufferers with kind 1 diabetes, but their efficacy and security for people with kind 2 diabetes stay much less established. Prior research have both lacked randomized managed designs or concerned restricted pattern sizes, creating a spot in medical understanding.

Whereas drugs resembling glucagon-like peptide 1 (GLP-1) receptor agonists and sodium–glucose cotransporter 2 (SGLT2) inhibitors assist some people obtain glucose targets, a considerable variety of insulin-treated sufferers proceed to wrestle with glycemic management.

Within the examine, “A Randomized Trial of Automated Insulin Supply in Kind 2 Diabetes,” printed in The New England Journal of Medication, researchers performed a multicenter randomized managed trial to evaluate the efficacy and security of AID in adults utilizing a number of each day insulin injections or insulin pumps.

A complete of 319 sufferers throughout 21 facilities in the US and Canada participated. Sufferers had been randomly assigned in a 2:1 ratio to both the AID group, which acquired the t:slim X2 insulin pump with Management-IQ+ know-how and a Dexcom G6 sensor, or the management group, which continued their pretrial insulin routine whereas utilizing real-time unblinded CGM.

Baseline HbA1c ranges averaged 8.2% (±1.4) within the AID group and eight.1% (±1.2) within the management group. Over 13 weeks, HbA1c decreased to 7.3% (±0.9) within the AID group and seven.7% (±1.1) within the management group. A distinction of –0.6 proportion factors was noticed between the teams.

CGM knowledge indicated a rise in time spent inside the goal glucose vary (70–180 mg/dL) from 48% (±24) to 64% (±16) within the AID group and from 51% (±21) to 52% (±21) within the management group. An adjusted distinction of 14 proportion factors was recorded, equating to three.4 extra hours per day spent within the goal glucose vary with AID.

Further CGM-based measures of hyperglycemia confirmed vital enchancment within the AID group. Imply glucose ranges decreased by 21 mg/dL. Time spent with glucose ranges above 250 mg/dL decreased by 9.1 proportion factors.

Low ranges of CGM-measured hypoglycemia had been noticed in each teams. One extreme hypoglycemia occasion was reported within the AID group, with no occurrences within the management group. No circumstances of diabetic ketoacidosis or hyperosmolar hyperglycemic syndrome had been recorded.

Some 44% of contributors had been on GLP-1 receptor agonists, 37% on SGLT2 inhibitors, and 21% on each. Subgroup analyses confirmed that AID delivered constant advantages no matter particular drugs. There was a 93% median time spent in computerized mode, suggesting robust adherence or ease of use.

Findings recommend AID could also be a invaluable instrument for managing insulin-treated kind 2 diabetes, even amongst sufferers with no prior expertise utilizing insulin pumps or carbohydrate counting strategies.

Extra info:
Yogish C. Kudva et al, A Randomized Trial of Automated Insulin Supply in Kind 2 Diabetes, New England Journal of Medication (2025). DOI: 10.1056/NEJMoa2415948

© 2025 Science X Community

Quotation:
Automated insulin supply improves glycemic management of kind 2 diabetes in randomized trial (2025, March 22)
retrieved 22 March 2025
from https://medicalxpress.com/information/2025-03-automated-insulin-delivery-glycemic-diabetes.html

This doc is topic to copyright. Aside from any truthful dealing for the aim of personal examine or analysis, no
half could also be reproduced with out the written permission. The content material is offered for info functions solely.



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Tags: automatedcontrolDeliverydiabetesglycemicImprovesinsulinrandomizedtrialType
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