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AbbVie Enters Obesity Field, Paying $350M for Amylin Receptor Agonist Already in the Clinic

March 3, 2025
in Health
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AbbVie is becoming a member of the chase for brand spanking new weight problems medication, however somewhat than getting a me-too GLP-1 drug, the pharmaceutical large is touchdown rights to a clinical-stage molecule that goes after two novel targets to set off weight reduction.

Beneath deal phrases introduced Monday, AbbVie can pay Danish firm Gubra $350 million up entrance for rights to its drug, GUB014295. AbbVie will lead additional medical improvement in addition to commercialization. Gubra might obtain as much as $1.875 million in milestone funds, plus royalties from gross sales of an accepted product.

AbbVie’s Allergan Aesthetics division has a presence in focused fats discount with CoolSculpting, a nonsurgical medical machine. The corporate doesn’t market this providing as a therapy for weight reduction or weight problems. GUB014295 provides AbbVie entry right into a rising subject of weight problems drug contenders.

Gubra’s drug is a peptide engineered to be an analog for amylin, a hormone that helps regulate blood sugar and meals consumption. It’s particularly designed to bind to and activate amylin and calcitonin receptors, each of which play roles in regulating features of metabolism, resembling urge for food. The once-weekly injectable drug, additionally identified internally as GUBamy, is meant to spark indicators to the mind that suppress urge for food to scale back meals consumption. This strategy additionally prompts an inhibitory sign that delays gastric emptying to assist sufferers really feel fuller.

Final November, Gubra introduced encouraging preliminary Part 1 knowledge displaying a single dose of GUB014925 led to three% weight reduction that was sustained for the six weeks of the trial. The placebo group confirmed 1% weight achieve. The corporate added that the examine drug was nicely tolerated and unwanted effects have been gastrointestinal, which is per different weight problems medication. These adversarial occasions have been categorized as delicate and transient. Extra particularly, nausea and decreased urge for food have been described as frequent whereas vomiting was occasional. Higher security and tolerability might provide a method for AbbVie to face aside in a crowded subject of weight problems drug candidates.

“Weight problems represents a big world well being concern with practically 900 million adults with weight problems, a lot of whom battle to remain on present therapy choices,” stated Roopal Thakkar, govt vice chairman, analysis & improvement, chief scientific officer, AbbVie, stated in a ready assertion. “Constructing on Gubra’s expertise within the discovery of novel peptide-based therapeutics, we sit up for advancing the event of the GUB014295 program.”

A multiple-ascending dose check of GUB014925 is designed with two components. Half A is testing two doses for six-weeks; Gubra has stated preliminary knowledge are anticipated in April. Half B is testing three extra doses for 12 weeks. Dosing on this half is anticipated to be full within the fourth quarter of this 12 months.

In a be aware despatched to traders, analysts at William Bliar stated they imagine AbbVie’s licensing deal for the Gubra drug highlights rising curiosity in amylin agonists, significantly these medication that take a twin strategy by activating each amylin and calcitonin receptors. This strategy provide a method for corporations to interrupt into the weight problems subject regardless of being behind the 2 blockbuster GLP-1 medication, Wegovy from Novo Nordisk and Zepbound from Eli Lilly. The William Blair analysts added {that a} key query is whether or not AbbVie plans to develop GUB014295 as a monotherapy, which may very well be higher tolerated, or as a part of a mixture with GLP-1/GIP agonist medication to probably drive larger weight reduction.

Novo Nordisk’s efforts to increase its management place in weight problems merchandise contains medication that go after two targets to spark weight reduction. The pharma large’s amycretin is a peptide engineered to activate GLP-1 and amylin receptors. In preliminary Part 1b/2a outcomes launched in January, the very best dose of the once-weekly injection led to 22% weight reduction measured at 36 weeks.

Final month, Metsera raised $275 million from its IPO to assist improvement of its most superior program, a longer-acting GLP-1 agonist in Part 1/2 testing. The biotech’s pipeline additionally contains an ultra-long performing amylin receptor agonist. Zealand Pharma has reached mid-stage medical improvement with petrelintide, a long-acting amylin analog that might provide weight reduction similar to GLP-1 medication. However Zealand additionally says this drug might provide higher tolerability and muscle preservation, addressing the muscle loss that’s one other identified adversarial impact of at the moment obtainable weight problems drugs. In the meantime, the pipeline of Viking Therapeutics features a preclinical weight problems program concentrating on the amylin and calcitonin receptors.

Picture: Smith Assortment/Gado, by way of Getty Photos



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Tags: 350MAbbVieAgonistAmylinClinicEntersfieldObesitypayingReceptor
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