Tuesday, June 3, 2025
VISIT ROYALMOK
Agarwood Times
  • Home
  • Agarwood
  • Health
  • Diseases
  • Diet & Fitness
  • Nutrition
  • Sleep Info
  • Meditation
  • Shop
No Result
View All Result
  • Home
  • Agarwood
  • Health
  • Diseases
  • Diet & Fitness
  • Nutrition
  • Sleep Info
  • Meditation
  • Shop
No Result
View All Result
Agarwood Times
No Result
View All Result

A strategy for treating metastatic breast cancer

August 28, 2024
in Health
Reading Time: 3 mins read
0 0
A A
0
Home Health
Share on FacebookShare on Twitter


miR-10b Inhibition: A strategy for treating metastatic breast cancer

miR-10b inhibition by MN-anti-miR10b decreases Aldefluor accumulation and impairs spheroid formation. (A) Fluorescence microscopy of consultant MDA-MB-231 cells after incubation with Aldefluor reagent. (B) Fluorescence microscopy of consultant MCF-7 cells after incubation with Aldefluor reagent. A and B: Imply sign depth = imply grey worth in ImageJ. (C) Mammosphere formation over time of MCF-7 cells handled with MN-anti-miR10b or MN 48 hours previous to (adherent circumstances) and through tradition in mammosphere medium. (D) Spheroid dimension (left) and amount in a area of view (proper) of MCF-7 spheroids at Day 7 in handled medium. Plots symbolize imply ± SEM (left) and imply ± max/min (proper). (E) Viability assay of MCF-7 spheroids at Day 7 in handled medium. Credit score: Halim et al.

A brand new analysis paper was printed in Oncotarget, titled “Inhibition of miR-10b treats metastatic breast most cancers by concentrating on stem cell-like properties.”

As acknowledged inside the paper, regardless of advances in breast most cancers screening and remedy, the prognosis for metastatic illness stays dismal, with solely a 30% five-year survival fee. This poor end result is basically because of the failure of present therapeutics to focus on the distinctive properties of metastatic cells. One of many key drivers of metastasis is miR-10b, a small noncoding RNA implicated in most cancers cell invasion, migration, viability, and proliferation.

Researchers Alan Halim, Nasreen Al-Qadi, Elizabeth Kenyon, Kayla N. Conner, Sujan Kumar Mondal, Zdravka Medarova, and Anna Moore from Michigan State College’s Precision Well being Program, School of Human Drugs, and School of Veterinary Drugs, and Transcode Therapeutics Inc. in Newton, Massachusetts, present transcriptional proof that inhibiting miR-10b with MN-anti-miR10b—a nanodrug designed to ship anti-miR-10b antisense oligomers to most cancers cells—prompts developmental processes in most cancers cells. They noticed elevated miR-10b expression in stem-like most cancers cells.

In mouse fashions of metastatic triple-negative breast most cancers, MN-anti-miR10b has been proven to stop the onset of metastasis and get rid of current metastases when mixed with chemotherapy, even after remedy has been discontinued.

“Our outcomes display that inhibition of miR-10b utilizing MN-anti-miR10b decreases the stemness of breast most cancers cells, supporting dedifferentiation as a mechanism by way of which the nanodrug might perform as a remedy,” defined the researchers.

Extra info:
Alan Halim et al, Inhibition of miR-10b treats metastatic breast most cancers by concentrating on stem cell-like properties, Oncotarget (2024). DOI: 10.18632/oncotarget.28641

Offered by
Impression Journals LLC

Quotation:
miR-10b inhibition: A technique for treating metastatic breast most cancers (2024, August 28)
retrieved 28 August 2024
from https://medicalxpress.com/information/2024-08-mir-10b-inhibition-strategy-metastatic.html

This doc is topic to copyright. Aside from any truthful dealing for the aim of personal examine or analysis, no
half could also be reproduced with out the written permission. The content material is supplied for info functions solely.



Source link

Tags: breastcancermetastaticstrategytreating
Previous Post

Lilly’s Zepbound price cut could help customers — and boost profits

Next Post

The Surprising Rivalries-Turned-Friendships That Are Shaping Diabetes Technology

Related Posts

Eating healthier can protect aging brain
Health

Eating healthier can protect aging brain

June 2, 2025
New genetically modified fruit fly model sheds light on cocaine addiction
Health

New genetically modified fruit fly model sheds light on cocaine addiction

June 2, 2025
Allina Health Sees Early Success From Voice AI in Call Centers
Health

Allina Health Sees Early Success From Voice AI in Call Centers

June 2, 2025
AstraZeneca, Genentech, Roche, Takeda Day 3 news
Health

AstraZeneca, Genentech, Roche, Takeda Day 3 news

June 2, 2025
Exercise boosts survival rates in colon cancer patients, study shows
Health

Exercise boosts survival rates in colon cancer patients, study shows

June 1, 2025
Healthy food choices found to be key in reducing heart disease risk
Health

Healthy food choices found to be key in reducing heart disease risk

June 1, 2025
Next Post
The Surprising Rivalries-Turned-Friendships That Are Shaping Diabetes Technology

The Surprising Rivalries-Turned-Friendships That Are Shaping Diabetes Technology

Africa’s mpox cases continue steady rise; first vaccine doses arrive in Nigeria

Africa’s mpox cases continue steady rise; first vaccine doses arrive in Nigeria

CDC snapshot details Oropouche virus infection in 21 travelers to Cuba

CDC snapshot details Oropouche virus infection in 21 travelers to Cuba

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

RECOMMENDED

Plastic particles found in food could harm the body
Diseases

Plastic particles found in food could harm the body

by admin
June 1, 2025
0

Credit score: CC0 Public Area Outcomes from a brand new animal research counsel that microscopic plastic particles present in meals...

Agarwood tree price in Assam / Agarwood tree plant / Agarwood tree price in India #agarwoodfarming

Agarwood tree price in Assam / Agarwood tree plant / Agarwood tree price in India #agarwoodfarming

May 28, 2025
Exercise boosts survival rates in colon cancer patients, study shows

Exercise boosts survival rates in colon cancer patients, study shows

June 1, 2025
AstraZeneca, Genentech, Roche, Takeda Day 3 news

AstraZeneca, Genentech, Roche, Takeda Day 3 news

June 2, 2025
Colorful Vegan Confetti Potato Salad with Creamy Lemon Dressing

Colorful Vegan Confetti Potato Salad with Creamy Lemon Dressing

June 1, 2025
Agarwood Incense, Meditation, Relaxing, Healing #oudhserenity #agarwood #whiteoud #relaxationmusic

Agarwood Incense, Meditation, Relaxing, Healing #oudhserenity #agarwood #whiteoud #relaxationmusic

May 31, 2025
Facebook Twitter Instagram Youtube RSS
Agarwood Times

Stay informed with the latest news, articles, and insights on agarwood cultivation, history, sustainability, and more. Explore the timeless allure of agarwood and deepen your understanding of this extraordinary natural resource.

CATEGORIES

  • Agarwood
  • Diet & Fitness
  • Diseases
  • Health
  • Meditation
  • Nutrition
  • Sleep Info
  • Uncategorized
No Result
View All Result

SITEMAP

  • About us
  • Advertise With Us
  • Disclaimer
  • Privacy Policy
  • DMCA
  • Cookie Privacy Policy
  • Terms and Conditions
  • Contact us

Copyright © 2024 Agarwood Times.
Agarwood Times is not responsible for the content of external sites.

No Result
View All Result
  • Home
  • Agarwood
  • Health
  • Diseases
  • Diet & Fitness
  • Nutrition
  • Sleep Info
  • Meditation
  • Shop
VISIT ROYALMOK

Copyright © 2024 Agarwood Times.
Agarwood Times is not responsible for the content of external sites.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In