Coronary heart illness is the primary explanation for dying for girls within the U.S., however girls with cardiovascular danger elements typically don’t get the remedy they want till it’s too late. In response to emailed questions, Systole Well being CEO and Co-founder Dr. Simin Gharib Lee talked about how her firm is addressing this medical want.
Why did you begin this firm?
I began Systole as a result of I stored seeing the identical drawback over and over: girls exhibiting up in my clinic submit pandemic with weight achieve, hypertension, excessive ldl cholesterol, new diagnoses of prediabetes or diabetes, and a few with their first coronary heart assaults. They had been caught in a fragmented system that wasn’t constructed to assist them. They bounced between overwhelmed main care docs and specialist waitlists, generally ready as much as two years to even begin remedy.
The truth is, we don’t have sufficient cardiologists to care for each girl in danger for coronary heart illness. And those who do get via typically spend just some rushed minutes with their physician earlier than being despatched on their means.
I knew there needed to be a greater means. What if we gave girls time, entry, training, and a way of neighborhood earlier than they ever developed a coronary heart assault or stroke? That’s why I constructed Systole — group digital care for girls’s cardiometabolic well being, led by skilled clinicians, designed to truly transfer the needle on prevention and remedy.

What want are you looking for to handle in healthcare?
Coronary heart illness is the primary killer of girls, however our healthcare system nonetheless doesn’t deal with it that means. Girls’s cardiovascular danger elements — hypertension, excessive ldl cholesterol, weight problems, metabolic dysfunction — are underdiagnosed, undertreated, and infrequently ignored till it’s too late. By the point many ladies obtain remedy, they’ve already suffered a coronary heart assault, coronary heart failure, or different severe cardiovascular occasion. And even then, their care stays fragmented, with little structured steerage on forestall one other occasion from taking place.
We even have a large entry drawback. There are merely not sufficient cardiologists, and the pipeline isn’t rising quick sufficient to maintain up with demand. Which means lengthy wait occasions, temporary visits, and numerous girls left in limbo with out the care they want.
Systole is fixing each issues — by providing complete, accessible, and evidence-based group digital care that scales. Whether or not a girl is in danger for coronary heart illness and needs to stop it, or has already had a cardiovascular occasion and wishes skilled assist to get well and keep wholesome, we offer the training, remedy, and neighborhood that conventional healthcare fails to ship.
What does your product do? How does it work?
Systole runs physician-led group digital visits for girls with coronary heart illness and people in danger. Consider it as a contemporary, scalable strategy to cardiovascular care — the place sufferers get extra time with skilled clinicians, extra training about their situation, and extra peer assist, reasonably than only a rushed 15-minute appointment that hardly scratches the floor.
Every 60-min session contains 8-10 girls, guided by a doctor and well being coach. Sufferers obtain structured medical care, personalised remedy changes, training on life-style interventions, and a collaborative house to truly perceive their coronary heart well being. Some try to stop their first coronary heart assault or coronary heart failure episode, whereas others want ongoing steerage to keep away from one other one.
And in contrast to many digital well being startups that function exterior of the system, we combine straight into present healthcare buildings — partnering with well being programs to increase their attain, cut back specialist bottlenecks, and enhance scientific outcomes. Whether or not a girl wants to stop her first cardiovascular occasion or her second, we make sure that she’s getting the correct care, on the proper time, with the assist she must succeed.
Is that this your first healthcare startup? What’s your background in healthcare?
I’m a Harvard-trained heart specialist with an MD/MBA, and I based Systole as a result of I knew I might have an even bigger impression exterior of the standard healthcare system. After years of seeing girls wrestle to entry the correct care — whether or not attempting to stop coronary heart illness or recovering from their first coronary heart assault — I noticed that our present mannequin merely doesn’t scale.
That is my first startup, however in some ways, I’ve been getting ready for this my whole profession. My MD taught me deal with coronary heart illness. My MBA taught me repair the system that retains failing girls. Systole is my means of doing each — constructing a care mannequin that’s not solely clinically rigorous but in addition scalable and financially viable, making certain that extra girls get the expert-led cardiovascular care they deserve.
What’s your organization’s enterprise mannequin?
Systole companions with well being programs and doctor teams to broaden entry to cardiovascular care, cut back wait occasions, and enhance outcomes for girls’s coronary heart well being — all whereas producing new income for suppliers.
Our mannequin is constructed on shared medical appointments (SMAs), a reimbursable, evidence-based strategy that enables suppliers to see a number of sufferers in a structured group setting, bettering engagement and outcomes whereas easing the burden on overextended clinics.
For well being programs, Systole presents:
Scalable entry enlargement – We combine straight into present workflows, serving to cardiology and first care groups handle at-risk girls who would possibly in any other case face lengthy wait occasions or fall via the cracks.
Monetary upside – Our visits are billed underneath commonplace E&M billing codes, creating a brand new income stream whereas opening capability to extend affected person throughput.
Stronger affected person retention and satisfaction – Girls in our program really feel extra supported, extra engaged, and extra knowledgeable, bettering outcomes and loyalty to the system.
Whereas we do provide direct-to-consumer entry, our main focus is partnering with well being programs to increase their attain, offload steady however high-risk sufferers, and create a extra sustainable and accessible mannequin for girls’s coronary heart care.
Who’s your buyer?
Systole’s main prospects are well being programs and doctor teams trying to broaden entry, enhance affected person outcomes, and create a extra sustainable mannequin for cardiovascular care. Our digital shared medical appointments permit them to dump steady however high-risk girls right into a structured, scalable program — serving to overburdened cardiologists and first care docs handle demand whereas preserving sufferers engaged of their well being.
Past well being programs, we see rising curiosity from payers and employers who acknowledge the long-term value financial savings of proactive cardiovascular care. With rising charges of heart problems and obesity-related situations, early intervention and danger issue optimization are important cost-control methods. They’ll maintain sufferers more healthy, decreasing avoidable hospitalizations, and stopping downstream issues.
Our typical affected person is a girl in midlife — typically navigating hypertension, excessive ldl cholesterol, metabolic dysfunction, or recovering from a latest cardiovascular occasion. Many of those girls wrestle to get well timed care, both because of lengthy specialist wait occasions or an absence of structured assist in main care.
By working with well being programs, payers, and employers, we guarantee these girls don’t get misplaced within the system, whereas giving suppliers a software to handle danger extra successfully.
How do you generate income?
We generate income via three main streams:
Insurance coverage reimbursement for group digital visits, that are billable companies lined by CMS and personal insurers.
Well being system and employer partnerships, the place we provide a turn-key resolution to assist them broaden their specialty care choices.
Direct affected person enrollment, permitting girls to self-pay for quick entry to skilled coronary heart well being care.
This diversified income mannequin allows us to scale sustainably whereas making certain affordability and accessibility for sufferers.
Do you’ve gotten scientific validation on your product?
Sure, we do! Systole’s mannequin is rooted in sturdy proof for shared medical appointments, which have been proven to:
Enhance affected person engagement and adherence
Cut back specialist wait occasions
Improve scientific outcomes for power illness administration
Past revealed knowledge, we’ve already seen real-world impression: lots of our early cohort sufferers have achieved blood strain, ldl cholesterol, and/or weight management, whereas additionally being screened for high-risk lipid problems — all inside an environment friendly 6-week timeframe.
We’re additionally monitoring affected person engagement and well being outcomes carefully to construct a rising physique of scientific proof particular to Systole’s program. Our long-term imaginative and prescient is to set a brand new commonplace for scalable, high-quality digital cardiovascular care for girls.
Picture: BrianAJackson, Getty Photographs
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