A low omega-6, omega-3 rich diet and fish oil may slow prostate cancer growth

A examine led by UCLA Well being Jonsson Complete Most cancers Middle investigators gives new proof that dietary adjustments could assist scale back most cancers cell development in sufferers present process lively surveillance, a therapy method that includes common monitoring of the most cancers with out speedy intervention.

The findings, printed within the Journal of Medical Oncology, present {that a} weight loss plan low in omega-6 and excessive in omega-3 fatty acids, mixed with fish oil dietary supplements, considerably lowered the expansion charge of prostate most cancers cells in males with early-stage illness.

“This is a vital step towards understanding how weight loss plan can doubtlessly affect prostate most cancers outcomes,” mentioned Dr. William Aronson, Professor of Urology on the David Geffen Faculty of Medication at UCLA and first creator of the examine.

“Many males are considering way of life adjustments, together with weight loss plan, to assist handle their most cancers and stop the development of their illness. Our findings counsel that one thing so simple as adjusting your weight loss plan might doubtlessly sluggish most cancers development and prolong the time earlier than extra aggressive interventions are wanted.”

Many males with low-risk prostate most cancers select lively surveillance over speedy therapy. Nevertheless, inside 5 years, about 50% of those males finally have to bear remedy with both surgical procedure or radiation. Due to this, sufferers are keen to seek out methods to delay the necessity for therapy, together with by means of dietary adjustments or dietary supplements.

Particular dietary pointers on this space have but to be established. Whereas different medical trials have checked out growing vegetable consumption and nutritious diet patterns, none have discovered a major impression on slowing most cancers development.

To find out whether or not weight loss plan or dietary supplements can play a task in managing prostate most cancers, the UCLA-led group carried out a potential medical trial, known as CAPFISH-3, that included 100 males with low threat or favorable intermediate threat prostate most cancers who selected lively surveillance. Individuals had been randomly assigned to both proceed their regular weight loss plan or comply with a low omega-6, excessive omega-3 weight loss plan, supplemented with fish oil, for one yr.

Individuals within the intervention arm obtained dietary personalised counseling from a registered dietitian nutritionist, both in-person, by means of telehealth or by cellphone. Sufferers had been guided on more healthy, decrease fats options for top fats/excessive calorie meals (equivalent to utilizing olive oil or lemon and vinegar for salad dressing), and on lowering consumption of meals with increased omega-6 content material (equivalent to, chips, cookies, mayonnaise and different fried or processed meals).

The purpose was to create a good steadiness of their consumption of omega-6 and omega-3 fat and make individuals really feel empowered to regulate how they alter their habits. They had been additionally given fish oil capsules for further omega-3s. The management group didn’t get any dietary counseling or take fish oil capsules.

The researchers tracked adjustments in a biomarker known as the Ki-67 index, which signifies how briskly most cancers cells are multiplying—a key predictor of most cancers development, metastasis and survival.

Similar web site biopsies had been obtained at first of the examine and once more after the one-year mark, utilizing a picture fusion machine that helps observe and find the most cancers websites.

Outcomes confirmed that the low omega-6, omega-3 wealthy weight loss plan and fish oil group had a 15% lower within the Ki-67 index, whereas the management group noticed a 24% enhance.

“This vital distinction means that the dietary adjustments could assist sluggish most cancers development, doubtlessly delaying and even stopping the necessity for extra aggressive remedies,” mentioned Aronson, who can also be the Chief of urologic oncology on the West Los Angeles Veterans Affairs Medical Middle and member of the UCLA Well being Jonsson Complete Most cancers Middle.

Whereas the outcomes are promising, researchers didn’t discover any variations in different most cancers development markers, equivalent to Gleason grade, that are generally used to trace prostate most cancers development.

The investigators warning that additional analysis is important to verify the long-term advantages of omega-3 fatty acids and decreasing omega-6 in managing prostate most cancers. The findings assist additional, bigger trials to discover the long-term impression of dietary adjustments on most cancers development, therapy outcomes and survival charges in males on lively surveillance.